ea0028p134 | Growth and development | SFEBES2012
Martinez Carolina
, Piazza Veronica
, Miquet Johanna
, Ramirez Maria
, Becu-Villalobos Damasia
, Bartke Andrzej
, Turyn Daniel
, Sotelo Ana
JAK2/STAT5 is the principal growth hormone (GH) signaling pathway related to body growth. It is positively regulated by glucocorticoid receptor (GR) and hepatocyte nuclear factor 1 (HNF-1) and downregulated by activation of tyrosine-phosphatases SHP-1,-2 and PTP-1B, and by GH-induction of suppressors of cytokine signaling (CIS/SOCS) that block GHR or JAK2, and promote internalization/degradation of signaling complexes. This pathway is desensitized in liver of adult transgenic ...